![]() Spectra-500 is used for the treatment of the following infections caused by sensitive bacteria: Ciprofloxain and its derivatives are also being investigated for its action against malaria, cancers, and AIDS. There is no cross resistance between fluoroquinolones and other classes of antibiotics, so it may be of clinical value when other antibiotics are no longer effective. Spectra-500 binds to bacterial DNA gyrase with 100 times the affinity of mammalian DNA gyrase. It produces its action through inhibition of bacterial DNA gyrase and topoisomerase IV. Spectra-500 is a second generation fluoroquinolone that is active against many Gram negative and Gram positive bacteria. It is a faint to light yellow crystalline powder with a molecular weight of 385.8. It is available as the monohydrochloride monohydrate salt of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)- 3-quinoline-carboxylic acid. Spectra-500 is a fluoroquinolone antibacterial active against a broad spectrum of gram positive and gram-negative ocular pathogens. Spectra-500 (Eye/Ear) drops (Spectra-500 Hydrochloride ophthalmic solution) is a synthetic, sterile, multiple dose, antimicrobial for topical use. About 30-50% of an oral dose of Spectra-500 is excreted in the urine within 24 hours as unchanged drug and active metabolites. The half-life of Spectra-500 is 3.5 - 4.5 hours. Spectra-500 is well absorbed from the GIT after oral administration and it is widely distributed into the body tissues and fluid. The mode of action of Spectra-500 is different from other antibiotics like penicillins, cephalosporins, aminoglycosides, tetracyclines and for this reason it is observed that organisms resistant to these antibiotics are susceptible to Spectra-500. The bactericidal activity of Spectra-500 results from interference with the enzyme DNA gyrase needed for the synthesis of bacterial DNA. ![]() However many strains of Streptococci are relatively resistant to the drug. Spectra-500 is also active against gram-positive aerobic bacteria including penicillinase producing, non-penicillinase producing and methicillin resistant Staphylococci. It is active against most gram-negative aerobic bacteria including Enterobacteriaceae and Pseudomonas aeruginosa. Spectra-500 is a synthetic 4-quinolone derivative with bactericidal activity against a wide range of gram-positive and gram-negative organism. ![]()
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